In 2001 The Saw Doctors released their fifth album, Villains? which featured the single, This Is Me.
A review on entertainment.ie declared that the album was the best the band had ever made.
After the album was completed, Pearse Doherty left the band and was replaced by Anthony Thistlethwaite who had been a session musician with the band since the 1980s as well as a member of The Waterboys.
Their next major release was a live album and DVD of a concert in Galway. They also released their 6th studio album, The Cure.
In 2006, they performed three songs at Celtic Park, Glasgow, before a European Champions League match between Celtic and Manchester United.
In 2008, the band were honoured with a lifetime achievement award at the Meteor Irish Music Awards. Later that year they scored their first number one single for 17 years with a cover of the Sugerbabes’ hit, About You Know.
In 2010 their 7th studio album, The Further Adventure of… The Saw Doctors, was released. They also performed at the 40th anniversary of Glastonbury festival.
The Saw Doctors are still going strong and still touring.